A methodological investigation of healthy tissue, hepatocellular carcinoma, and other lesions with dynamic 68Ga-FAPI-04 PET/CT imaging

Abstract Background The study aimed to establish a 68 Ga-FAPI-04 kinetic model in hepatic lesions, determine the potential role of parameters differentiation hepatocellular carcinoma (HCC) from non-HCC lesions. Material and methods Time activity curves (TACs) were extracted seven HCC lesions five obtained dynamic positron emission tomography (PET) scans eight patients. Three models applied TACs, using image-derived artery and/or portal vein as input functions. maximum standardized uptake value (SUV max ) was taken for artery, veins—the mean SUV all healthy regions. optimum chosen after applying Schwartz information criteria differences between HCC, tissue evaluated with ANOVA test. Results A reversible two-tissue compartment both arterial well venous function most preferred showed significant V ND , T BP regions ( p < 0.01). Conclusion Several derived two aorta allow dynamically performed PET FAPI.